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Animal Rights

June 26, 2020 - Science AAAS

Is it time to replace one of the cornerstones of animal research?

Is it time to replace one of the cornerstones of animal research?
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Last year marked the 60th anniversary of one of the most influential concepts in lab animal welfare—the three Rs. To promote the humane treatment of laboratory animals, these principles urge scientists to replace animals with new technologies, reduce the number of animals used in experiments, and refine lab protocols to minimize animal suffering. First outlined in the 1959 book, The Principles of Humane Experimental Technique, the three Rs have become a cornerstone of lab animal legislation and oversight throughout the world.

But as millions of animals continue to be used in biomedical research each year, and new legislation calls on federal agencies to reduce and justify their animal use, some have begun to argue that it’s time to replace the three Rs themselves. “It was an important advance in animal research ethics, but it’s no longer enough,” Tom Beauchamp told attendees last week at a lab animal conference.

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